Acute and Subacute Toxicity of Oxalis barrelieri (Oxalidaceae) Aqueous Aerial Parts Extract

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Christophe Mezui
André Perfusion Amang
Rigobert Espoir Ayissi Mbomo
Mimosette Mesmine Kuissu Teukam
Merveille-Celeste Lontsi-Nolah
Yolande Mossebo Toungainbo
Paul Vernyuy Tan


Aims: The present study was carried out to investigate the toxic effects of the Oxalis barrelieri aqueous aerial parts extract.

Place and Duration of Study: Department of Biological Sciences (Animal Physiology Laboratory), Higher Teachers’ Training College, University of Yaoundé I. Between April 2017 and June 2018.

Materials and Methods: Acute toxicity using a single dose of 2000 mg/kg was administered to mice and effects were observed for 14 days. In sub-acute toxicity, the experimental rats (males and females) received aqueous extract of Oxalis barrelieri at doses of 200 mg/kg, 400 mg/kg and 800 mg/kg daily for 28 days while the control and satellite control groups received distilled water and satellite test group received extract at the dose of 800 mg/kg. The physical parameters were evaluated throughout the treatment, while the haematological, biochemical and histological parameters were evaluated at the end of the treatment.

Results: In acute toxicity, the results obtained show no death and no significant variation (p>0.05) in behavioral and morphological parameters. In sub-acute toxicity assay, few modifications were observed in haematological and biochemical parameters. At the higher dose of extract (800 mg/kg),the rate of red blood cells decreased significantly (p<0.05) two weeks after treatment in male rats , there were a significant increase (P˂0.001) in ASAT activity in male and female rats two weeks after extract administration, and a reversible significant increase (P˂0.05) in triglyceride level in male rats only. Histopathology showed a reversible slight dose dependent structural alteration of the kidney and reversible vascular congestion in liver.

Conclusion:  The aqueous aerial parts extract of Oxalis barrelieri could possess moderate toxicity at high doses and adequate caution should be exercised in its use in ethnomedicine.

Oxalis barrelieri, aqueous extract, acute toxicity, sub-acute toxicity, oxalidaceae

Article Details

How to Cite
Mezui, C., Amang, A., Mbomo, R. E., Teukam, M. M., Lontsi-Nolah, M.-C., Toungainbo, Y., & Tan, P. (2019). Acute and Subacute Toxicity of Oxalis barrelieri (Oxalidaceae) Aqueous Aerial Parts Extract. Journal of Advances in Biology & Biotechnology, 22(2), 1-13.
Original Research Article


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