Mucosal Opened Cavities as the Organ of Increased Resistance and Effectiveness
M. V. Lakhtin
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Admiral Makarov Street 10, Moscow 125212, Russia
V. M. Lakhtin *
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Admiral Makarov Street 10, Moscow 125212, Russia
S. S. Afanasiev
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Admiral Makarov Street 10, Moscow 125212, Russia
V. A. Aleshkin
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Admiral Makarov Street 10, Moscow 125212, Russia
*Author to whom correspondence should be addressed.
Abstract
New aspects of human mucosal cavity protection systems are under consideration. On the basis of own data it was suggested that mucosal cavities function as mucosal organs. New players of mucosal organ were proposed. They included system probiotic lectins and probiotic microorganisms, and system synthetic polymeric multivalence pattern glycoconjugates. Resulting interacting biotope pro/synbiotic system of microbes, lectins and glycoconjugates (mucin-like or imitating, antigens and others) was suggested to communicate to other glycoconjugates-recognizing molecules and receptors of the human higher hierarchic protection systems. Conception of functioning mucosal organs is supported by own proposals, strategies, approaches, methods and algorithms. The data are also useful for constructing biotope pro/synbiotic microbiocenoses for application in medical biotechnology.
Keywords: Mucosal organ, mucosal barrier, biotope, microbiocenosis, probiotic, lectin, glycoconjugate, antimicrobial, synbiotic system, leader microorganism, pathogen