Nanomaterials in Biomedical Applications: A Review
Rashmi Mohapatra *
Department of Botany, Centre for Indigenous Knowledge on Herbal Medicines and Therapeutics, Kalinga Institute of Social Sciences (KISS), Deemed to be University, Bhubaneswar, Odisha – 751024, India.
Damayanti Giri
School of Comparative Indic Studies and Tribal Science, Department of Botany, Kalinga Institute of Social Sciences (KISS), Deemed to be University, Bhubaneswar, Odisha-751024, India.
D. Vijayakumar
Department of Biomedical Engineering, Mahendra Institute of Technology (Autonomous), Mallasamudram - 637503, Namakkal District, Tamil Nadu, India.
S. Alagendran
Department of Biochemistry, Dhanalakshmi Srinivasan Agriculture College, (Affiliated to Tamil Nadu Agricultural University, Coimbatore-3) Perambalur -621212. Tamil Nadu, India.
Dra. Gabriela Fernández Saavedra
Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, University City, C.P. 04510, Coyoacán, México City, Mexico.
Jay Prasad Jena
Kalinga Institute of Social Sciences, Deemed to be University, Bhubaneswar, Odisha – 751024, India.
S. Sridharan
School of Agricultural Sciences, Dhanalakshmi Srinivasan University, Perambalur 621 212, Tamil Nadu, India.
K. Karthikeyan
Department of Food Science and Nutrition, Periyar University, Salem, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Nanomaterials exhibit unique physicochemical properties, including exceptional surface-to-volume ratios, tunable optical and electronic characteristics, and enhanced reactivity, positioning them as pivotal tools in biomedical applications. This review systematically explores various classes of nanomaterials metallic nanoparticles, carbon-based nanostructures, polymeric nanoparticles, lipid-based nanoparticles, quantum dots, and hybrid or composite materials highlighting their biomedical functionalities in drug delivery, diagnostics, cancer therapy, tissue engineering, wound healing, and biosensing applications. The size, shape, surface charge, biocompatibility, biodegradability, and optical properties of these materials significantly influence their interactions within biological systems, determining therapeutic efficacy and diagnostic accuracy. Nanomaterials such as gold and silver nanoparticles demonstrate promising therapeutic and antimicrobial capabilities, while carbon-based materials, including carbon nanotubes and graphene derivatives, provide superior mechanical and conductive properties beneficial in advanced diagnostic and therapeutic approaches. Polymeric and lipid-based nanoparticles have been effectively utilized in targeted drug delivery systems, owing to their biocompatibility, controlled drug release properties, and reduced toxicity profiles. Quantum dots offer unmatched imaging capabilities due to their quantum confinement effects, substantially improving the sensitivity and specificity of biomedical imaging techniques. Despite these advancements, toxicity concerns, including cytotoxicity, genotoxicity, bioaccumulation, and immunogenicity, pose significant barriers to clinical translation. Addressing these limitations involves standardized characterization protocols, improved surface functionalization strategies, and robust regulatory frameworks. Emerging trends like stimuli-responsive nanocarriers, theranostic platforms, and integration with artificial intelligence provide promising pathways to overcome current challenges, enhancing efficacy, safety, and personalization in nanomedicine. The continued advancement and interdisciplinary collaboration among researchers, industry, and regulatory authorities are imperative for realizing the full clinical and commercial potential of nanomaterials, thereby revolutionizing healthcare outcomes globally.
Keywords: Nanomaterials, biomedicine, nanoparticles, theranostics, cytotoxicity, drug-delivery, biosensors