Gastroprotective Effect of Nanocurcumin Particles against Indomethacin-induced Gastric Ulcer in Mice
Nguyen Thi Hieu Trang
Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam
Hoang Le Son *
Department of Biochemistry, School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City, Vietnam
*Author to whom correspondence should be addressed.
Abstract
Gastroprotective Effect of Nanocurcumin Particles against Indomethacin-induced Gastric Ulcer in Mice
This study aims to investigate the gastroprotective properties of nanocurcumin against indomethacin-induced gastric ulcer in mice. Nanocurcumin particles were prepared by top down method, yielding up to 15% (w/w), and the size was defined less than 100 nm in diameter. The particles were characterized by using scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic laser light scattering (DLS), and X-ray diffraction (XRD). Significant gastroprotective properties of prepared nanocurcumin against indomethacin-induced stomach ulcer in mice (20 mg/kg, body weight) was observed by evaluating the levels of LPO, GSH, CAL and total protein in stomach and histological examining stomach of mice. It is believed that nanocurcumin particles are capable of healing mucosal injury inhibiting acid secretion, and reducing free radicals against indomethacin-induced injury stomach in mice.
Keywords: Nanocurcumin, curcumin, indomethacin, gastric ulcer, mice model